Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis.

@article{Haudenschild2011VimentinCT,
  title={Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis.},
  author={Dominik R Haudenschild and Jianfen Chen and Nina Pang and Nikolai Steklov and Shawn Patrick Grogan and Martin K Lotz and Darryl D D'lima},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2011},
  volume={29 1},
  pages={20-5}
}
Actin and tubulin cytoskeletal components are studied extensively in chondrocytes, but less is known about vimentin intermediate filaments. In other cell types, vimentin is a determinant of cell stiffness and disruption of vimentin networks weakens the mechanical integrity of cells. Changes in vimentin organization correlate with osteoarthritis progression, but the functional consequences of these changes remain undetermined in chondrocytes. The objective of this study was to compare the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Cytoskeleton Aberrations in Alkaptonuric Chondrocytes.

Journal of cellular physiology • 2017
View 4 Excerpts
Highly Influenced

Biomechanical properties and mechanobiology of the articular chondrocyte.

American journal of physiology. Cell physiology • 2013
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Similar Papers

Loading similar papers…