Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro.

@article{Friederich1999VillinFI,
  title={Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro.},
  author={Evelyne Friederich and Katia Vancompernolle and Daniel Louvard and Jo{\"e}l Vandekerckhove},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 38},
  pages={26751-60}
}
Villin is an actin-binding protein of the intestinal brush border that bundles, nucleates, caps, and severs actin in a Ca(2+)-dependent manner in vitro. Villin induces the growth of microvilli in transfected cells, an activity that requires a carboxyl-terminally located KKEK motif. By combining cell transfection and biochemical assays, we show that the capacity of villin to induce growth of microvilli in cells correlates with its ability to bundle F-actin in vitro but not with its nucleating… CONTINUE READING

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