Villification: how the gut gets its villi.

@article{Shyer2013VillificationHT,
  title={Villification: how the gut gets its villi.},
  author={Amy E Shyer and T. Tallinen and Nandan L. Nerurkar and Zhiyan Wei and Eun Seok Gil and David L. Kaplan and Clifford J Tabin and Lakshminarayanan Mahadevan},
  journal={Science},
  year={2013},
  volume={342 6155},
  pages={212-8}
}
The villi of the human and chick gut are formed in similar stepwise progressions, wherein the mesenchyme and attached epithelium first fold into longitudinal ridges, then a zigzag pattern, and lastly individual villi. We find that these steps of villification depend on the sequential differentiation of the distinct smooth muscle layers of the gut, which restrict the expansion of the growing endoderm and mesenchyme, generating compressive stresses that lead to their buckling and folding. A… CONTINUE READING
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