Vildagliptin preserves the mass and function of pancreatic β cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

@inproceedings{Hamamoto2013VildagliptinPT,
  title={Vildagliptin preserves the mass and function of pancreatic β cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes},
  author={Sumiko Hamamoto and Yukiko Kanda and Masashi Shimoda and Fuminori Tatsumi and Katsuhiko Kohara and Kazuhito Tawaramoto and Mitsuru Hashiramoto and Kohei Kaku},
  booktitle={Diabetes, obesity & metabolism},
  year={2013}
}
AIM We investigated the molecular mechanisms by which vildagliptin preserved pancreatic β cell mass and function. METHODS Morphological, biochemical and gene expression profiles of the pancreatic islets were investigated in male KK-A(y) -TaJcl(KK-A(y) ) and C57BL/6JJcl (B6) mice aged 8 weeks which received either vildagliptin or a vehicle for 4 weeks. RESULTS Body weight, food intake, fasting blood glucose, plasma insulin and active glucagon-like peptide-1 were unchanged with vildagliptin… CONTINUE READING
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