Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats.

Abstract

BACKGROUND AND AIMS It is believed that oxidative stress plays a role in the pathogenesis of diabetes mellitus. Several strategies have been developed with the objective of minimizing diabetic complications. Among these, inhibitors of dipeptidyl peptidase-IV (DPP-IV), which act by blocking degradation of incretin hormones, glucagon-like peptide hormone (GLP… (More)
DOI: 10.1016/j.arcmed.2013.03.004

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