Vigilant Keratinocytes Trigger Pathogen-Associated Molecular Pattern Signaling in Response to Streptococcal M1 Protein

@article{Persson2015VigilantKT,
  title={Vigilant Keratinocytes Trigger Pathogen-Associated Molecular Pattern Signaling in Response to Streptococcal M1 Protein},
  author={Sandra T Persson and L. Wilk and M. Mörgelin and H. Herwald},
  journal={Infection and Immunity},
  year={2015},
  volume={83},
  pages={4673 - 4681}
}
  • Sandra T Persson, L. Wilk, +1 author H. Herwald
  • Published 2015
  • Biology, Medicine
  • Infection and Immunity
  • ABSTRACT The human skin exerts many functions in order to maintain its barrier integrity and protect the host from invading microorganisms. One such pathogen is Streptococcus pyogenes, which can cause a variety of superficial skin wounds that may eventually progress into invasive deep soft tissue infections. Here we show that keratinocytes recognize soluble M1 protein, a streptococcal virulence factor, as a pathogen-associated molecular pattern to release alarming inflammatory responses. We… CONTINUE READING
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