Corpus ID: 26835918

Vigilant Keratinocytes Trigger PAMP Signaling in Response to Streptococcal M1 Protein

  title={Vigilant Keratinocytes Trigger PAMP Signaling in Response to Streptococcal M1 Protein},
  author={Sandra T Persson and L. Wilk and M. M{\"o}rgelin and H. Herwald},
  • Sandra T Persson, L. Wilk, +1 author H. Herwald
  • Published 2017
  • The human skin exerts many functions in order to maintain its barrier integrity and protect the host from invading microorganisms. One such pathogen is Streptococcus pyogenes, which can cause a variety of superficial skin wounds that may eventually progress into invasive deep soft tissue infections. Here we show that keratinocytes recognize soluble M1 protein, a streptococcal virulence factor, as a PAMP to release alarming inflammatory responses. We found that this interaction initiates an… CONTINUE READING

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