Corpus ID: 26835918

Vigilant Keratinocytes Trigger PAMP Signaling in Response to Streptococcal M1 Protein

@inproceedings{Persson2017VigilantKT,
  title={Vigilant Keratinocytes Trigger PAMP Signaling in Response to Streptococcal M1 Protein},
  author={Sandra T Persson and L. Wilk and M. M{\"o}rgelin and H. Herwald},
  year={2017}
}
  • Sandra T Persson, L. Wilk, +1 author H. Herwald
  • Published 2017
  • The human skin exerts many functions in order to maintain its barrier integrity and protect the host from invading microorganisms. One such pathogen is Streptococcus pyogenes, which can cause a variety of superficial skin wounds that may eventually progress into invasive deep soft tissue infections. Here we show that keratinocytes recognize soluble M1 protein, a streptococcal virulence factor, as a PAMP to release alarming inflammatory responses. We found that this interaction initiates an… CONTINUE READING

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    References

    SHOWING 1-10 OF 53 REFERENCES
    M1 Protein Triggers a Phosphoinositide Cascade for Group A Streptococcus Invasion of Epithelial Cells
    • 46
    • PDF
    Soluble M1 protein of Streptococcus pyogenes triggers potent T cell activation
    • 61
    Keratinocyte proinflammatory responses to adherent and nonadherent group A streptococci.
    • 49
    • PDF
    The M1 Protein of Streptococcus pyogenes Triggers an Innate Uptake Mechanism into Polarized Human Endothelial Cells
    • 9
    • PDF
    Streptococcal M Protein: A Multipotent and Powerful Inducer of Inflammation1
    • 144
    • PDF
    M Protein, a Classical Bacterial Virulence Determinant, Forms Complexes with Fibrinogen that Induce Vascular Leakage
    • 310
    Streptococcal M1 Protein-Provoked CXC Chemokine Formation, Neutrophil Recruitment and Lung Damage Are Regulated by Rho-Kinase Signaling
    • 15
    • PDF
    Signaling to NF-kappaB by Toll-like receptors.
    • 744
    A Farewell to Arms: Streptococcal Strategies to Cope with Innate Immunity
    • 3