Vigilance-controlled quantified EEG in safety pharmacology.


The vigilance-controlled quantified EEG can be used either as a safety, or as a discovery pharmacology procedure. Put strategically into the preclinical development process of a drug, it can be useful for making the decision about the future research direction to be taken. The experimental approach described in this unit is based on the rat EEG. Even though there are considerable differences in function and structure between human and rat brain, the EEG response to psychoactive drugs and convulsants is similar in the two species. Thus, the rat EEG is generally a reliable predictor for human CNS drug effects.

DOI: 10.1002/0471141755.ph1006s11

Cite this paper

@article{Drmller2001VigilancecontrolledQE, title={Vigilance-controlled quantified EEG in safety pharmacology.}, author={Niklaus D{\"{u}rm{\"{u}ller and Roger D. Porsolt and Richard Scherschlicht}, journal={Current protocols in pharmacology}, year={2001}, volume={Chapter 10}, pages={Unit 10.6} }