Vigabatrin induces tonic inhibition via GABA transporter reversal without increasing vesicular GABA release.

@article{Wu2003VigabatrinIT,
  title={Vigabatrin induces tonic inhibition via GABA transporter reversal without increasing vesicular GABA release.},
  author={Yuanming Wu and Wengang Wang and George B Richerson},
  journal={Journal of neurophysiology},
  year={2003},
  volume={89 4},
  pages={2021-34}
}
Two forms of GABAergic inhibition coexist: fast synaptic neurotransmission and tonic activation of GABA receptors due to ambient GABA. The mechanisms regulating ambient GABA have not been well defined. Here we examined the role of the GABA transporter in the increase in ambient [GABA] induced by the anticonvulsant vigabatrin. Pretreatment of cultured rat hippocampal neurons with vigabatrin (100 microM) for 2-5 days led to a large increase in ambient [GABA] that was measured as the change in… CONTINUE READING