Vigabatrin and behaviour disturbances

@article{Sander1990VigabatrinAB,
  title={Vigabatrin and behaviour disturbances},
  author={Josemir W Sander and Yvonne M. Hart},
  journal={The Lancet},
  year={1990},
  volume={335}
}
We have been using vigabatrin in clinical trials and on a named-patient basis on compassionate grounds for the past three years. We have treated 145 patients who had intractable seizure disorders, with varying degrees of success: 47% showed a definite improvement in seizure control. 44 patients experienced side-effects, most of these occurring early in treatment, and in 31 patients they were sufficiently severe to warrant withdrawal of the drug. We urge caution when starting vigabatrin… Expand

Paper Mentions

Vigabatrin use in psychotic epileptic patients: report of a prospective pilot study
TLDR
None of the subjects presented episodes that could be interpreted as psychotic reactions and, moreover, some patients showed a reduction in stereotypies, instability and aggressiveness, and an improvement in cognitive functions was observed. Expand
Retrospective study of vigabatrin and psychiatric behavioural disturbances
  • I. Wong
  • Medicine
  • Epilepsy Research
  • 1995
TLDR
The results suggest that a low starting does of vigabatrin does not reduce the risk of psychiatric and behavioural ADRs or prevent a more overt psychotic reaction from occurring. Expand
Vigabatrin in intractable childhood epilepsy: a retrospective study.
TLDR
Children with complex partial seizures, with or without secondary generalization, responded best with more than one-half achieving a greater than 50% reduction; generalized tonic-clonic seizures also improved but there was no significant change in absence or myoclonic seizures. Expand
Psychotic and severe behavioural reactions with vigabatrin: a review
TLDR
Behavioural reactions are uncommon with vigabatrin, and have not been shown to be greater with it than with other antiepileptic agents, therefore, it maybe inappropriate to withhold the drug from those who may benefit from it. Expand
Vigabatrin and psychosis.
TLDR
Vigabatrin should be started with caution in patients with severe epilepsy, particularly in the presence of a previous history of psychosis, and such patients should be carefully monitored. Expand
Vigabatrin-Associated Reversible Acute Psychosis in a Child
TLDR
Caution must be taken in children with predisposing factors at the beginning of vigabatrin therapy, especially in the early stages of treatment. Expand
Effects of vigabatrin on partial seizures and cognitive function.
TLDR
Vigabatrin was associated with a significant reduction in a measure of motor speed and overall score on a design learning test in the first 20 weeks of treatment, and was associatedWith a significant reduced in median complex partial seizure frequency four to 12 and 12 to 20 weeks after commencing vigab atrin. Expand
Pharmacotherapy of mania: A review
TLDR
This paper attempts to review the evidence of efficacy of the various antimanic agents, with a focus on the novel anticonvulsant and neuroleptic drugs, and to discuss the data available on these novel therapeutic options. Expand
Behavioural Effects of the New Anticonvulsants
TLDR
Positive behavioural effects have been described with several of the new anticonvulsants, particularly gabapentin, lamotrigine and oxcarbazepine; all of these drugs may have mood-levelling effects that could be of value in treating affective disorders. Expand
Vigabatrin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy and disorders of motor control.
TLDR
Current evidence supports a trial of this agent as adjunctive therapy in patients with refractory seizure disorders, and future investigation of vigabatrin monotherapy and its efficacy relative to established agents is awaited with interest. Expand
...
1
2
3
4
5
...