Vigabatrin and behaviour disturbances

  title={Vigabatrin and behaviour disturbances},
  author={Josemir W Sander and Yvonne M. Hart},
  journal={The Lancet},
We have been using vigabatrin in clinical trials and on a named-patient basis on compassionate grounds for the past three years. We have treated 145 patients who had intractable seizure disorders, with varying degrees of success: 47% showed a definite improvement in seizure control. 44 patients experienced side-effects, most of these occurring early in treatment, and in 31 patients they were sufficiently severe to warrant withdrawal of the drug. We urge caution when starting vigabatrin… Expand

Paper Mentions

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None of the subjects presented episodes that could be interpreted as psychotic reactions and, moreover, some patients showed a reduction in stereotypies, instability and aggressiveness, and an improvement in cognitive functions was observed. Expand
Retrospective study of vigabatrin and psychiatric behavioural disturbances
  • I. Wong
  • Medicine
  • Epilepsy Research
  • 1995
The results suggest that a low starting does of vigabatrin does not reduce the risk of psychiatric and behavioural ADRs or prevent a more overt psychotic reaction from occurring. Expand
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Children with complex partial seizures, with or without secondary generalization, responded best with more than one-half achieving a greater than 50% reduction; generalized tonic-clonic seizures also improved but there was no significant change in absence or myoclonic seizures. Expand
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Behavioural reactions are uncommon with vigabatrin, and have not been shown to be greater with it than with other antiepileptic agents, therefore, it maybe inappropriate to withhold the drug from those who may benefit from it. Expand
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Vigabatrin was associated with a significant reduction in a measure of motor speed and overall score on a design learning test in the first 20 weeks of treatment, and was associatedWith a significant reduced in median complex partial seizure frequency four to 12 and 12 to 20 weeks after commencing vigab atrin. Expand
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Vigabatrin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy and disorders of motor control.
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