Vif of feline immunodeficiency virus from domestic cats protects against APOBEC3 restriction factors from many felids.

@article{Zielonka2010VifOF,
  title={Vif of feline immunodeficiency virus from domestic cats protects against APOBEC3 restriction factors from many felids.},
  author={J{\"o}rg Zielonka and Daniela Marino and Henning Hofmann and Naoya Yuhki and Martin L{\"o}chelt and Carsten M{\"u}nk},
  journal={Journal of virology},
  year={2010},
  volume={84 14},
  pages={7312-24}
}
To get more insight into the role of APOBEC3 (A3) cytidine deaminases in the species-specific restriction of feline immunodeficiency virus (FIV) of the domestic cat, we tested the A3 proteins present in big cats (puma, lion, tiger, and lynx). These A3 proteins were analyzed for expression and sensitivity to the Vif protein of FIV. While A3Z3s and A3Z2-Z3s inhibited Deltavif FIV, felid A3Z2s did not show any antiviral activity against Deltavif FIV or wild-type (wt) FIV. All felid A3Z3s and A3Z2… CONTINUE READING