Viewpoint on handling anti-TNF failure in psoriasis

@article{Bracke2013ViewpointOH,
  title={Viewpoint on handling anti-TNF failure in psoriasis},
  author={Stefanie Bracke and Jo Lambert},
  journal={Archives of Dermatological Research},
  year={2013},
  volume={305},
  pages={945-950}
}
An association among the occurrence of antidrug antibodies (ADAs), diminished trough serum drug levels (TSDLs) and non-response or loss of response has been described for several tumor necrosis factor alpha (TNF) blocking agents in a variety of diseases, including psoriasis. In a series of ten psoriasis patients with primary or secondary failure, or adverse reactions during anti-TNF therapy, we measured ADAs and TSDLs in patient serum using radioimmunoassay and ELISA, respectively. By proposing… CONTINUE READING

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