Viewing the antigen‐induced initiation of B‐cell activation in living cells

  title={Viewing the antigen‐induced initiation of B‐cell activation in living cells},
  author={P. Tolar and Hae Won Sohn and Susan K. Pierce},
  journal={Immunological Reviews},
  • P. Tolar, Hae Won Sohn, Susan K. Pierce
  • Published 2008
  • Biology, Medicine
  • Immunological Reviews
  • Summary: The binding of antigen to the B‐cell receptor (BCR) induces BCR clustering and signaling cascades that lead to the activation of a variety of genes associated with B‐cell activation. Over the last several years, our understanding of the molecular details of the BCR signaling pathways have been considerably advanced; what remains only poorly understood are the molecular events that initiate BCR clustering and how clustering leads to activation. Here, we review our progress using live… CONTINUE READING
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