Viewing dynamic assembly of molecular complexes by multi-wavelength single-molecule fluorescence.

@article{Friedman2006ViewingDA,
  title={Viewing dynamic assembly of molecular complexes by multi-wavelength single-molecule fluorescence.},
  author={Larry J Friedman and Johnson Chung and Jeff Gelles},
  journal={Biophysical journal},
  year={2006},
  volume={91 3},
  pages={
          1023-31
        }
}
Complexes of macromolecules that transiently self-assemble, perform a particular function, and then dissociate are a recurring theme in biology. Such systems often have a large number of possible assembly/disassembly intermediates and complex, highly branched reaction pathways. Measuring the single-step kinetic parameters in these reactions would help to identify the functionally significant pathways. We have therefore constructed a novel single-molecule fluorescence microscope capable of… CONTINUE READING

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