Vidarabine versus acyclovir therapy in herpes simplex encephalitis.

  title={Vidarabine versus acyclovir therapy in herpes simplex encephalitis.},
  author={Richard J. Whitley and C. Alford and Martin S. Hirsch and Robert Turner Schooley and James Luby and Fred Y. Aoki and David Hanley and Andre Joseph Nahmias and S. J. Soong},
  journal={The New England journal of medicine},
  volume={314 3},
We randomly assigned 208 patients who underwent brain biopsy for presumptive herpes simplex encephalitis to receive either vidarabine (15 mg per kilogram of body weight per day) or acyclovir (30 mg per kilogram per day) for 10 days. Sixty-nine patients (33 percent) had biopsy-proved disease; 37 received vidarabine, and 32 acyclovir. The mortality in the vidarabine recipients was 54 percent, as compared with 28 percent in the acyclovir recipients (P = 0.008). Six-month mortality varied according… CONTINUE READING
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