Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4–VCAM-1 adhesion and macrophage inflammatory protein-1α and MIP-1β production

@article{Abe2008ViciousCB,
  title={Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4–VCAM-1 adhesion and macrophage inflammatory protein-1α and MIP-1β production},
  author={Masahiro Abe and Kenji Hiura and Shuji Ozaki and Shinsuke Kido and Toshio Matsumoto},
  journal={Journal of Bone and Mineral Metabolism},
  year={2008},
  volume={27},
  pages={16-23}
}
Multiple myeloma (MM) cell adhesion to stromal cells via very late antigen (VLA)-4 and vascular cell adhesion molecule (VCAM)-1 interaction causes enhanced secretion of osteoclastogenic activity by MM cells. We have reported that MM cell-derived macrophage inflammatory protein (MIP)-1α and MIP-1β are responsible for most of the osteoclastogenic activity in… CONTINUE READING