Vibrio cholerae tolC is required for bile resistance and colonization.

@article{Bina2001VibrioCT,
  title={Vibrio cholerae tolC is required for bile resistance and colonization.},
  author={James E Bina and John J Mekalanos},
  journal={Infection and immunity},
  year={2001},
  volume={69 7},
  pages={4681-5}
}
TolC and its homologues are outer membrane proteins that are essential for the transport of many molecules across the cell envelope. In this study we characterized the gene encoding Vibrio cholerae TolC. V. cholerae tolC mutants failed to secrete the RTX cytotoxin, were hypersensitive to antimicrobial agents, and were deficient in intestinal colonization. 
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