Vibrio cholerae porin OmpU induces LPS tolerance by attenuating TLR-mediated signaling.

@article{Sakharwade2015VibrioCP,
  title={Vibrio cholerae porin OmpU induces LPS tolerance by attenuating TLR-mediated signaling.},
  author={Sanica C. Sakharwade and Arunika Mukhopadhaya},
  journal={Molecular immunology},
  year={2015},
  volume={68 2 Pt A},
  pages={
          312-24
        }
}
Porins can act as pathogen-associated molecular patterns, can be recognized by the host immune system and modulate immune responses. Vibrio choleraeporin OmpU aids in bacterial survival in the human gut by increasing resistance against bile acids and anti-microbial peptides. V. choleraeOmpU is pro-inflammatory in nature. However, interestingly, it can also down-regulate LPS-mediated pro-inflammatory responses. In this study, we have explored how OmpU-pretreatment affects LPS-mediated responses… 
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