Vibrio cholerae flagellins induce Toll-like receptor 5-mediated interleukin-8 production through mitogen-activated protein kinase and NF-kappaB activation.

@article{Harrison2008VibrioCF,
  title={Vibrio cholerae flagellins induce Toll-like receptor 5-mediated interleukin-8 production through mitogen-activated protein kinase and NF-kappaB activation.},
  author={Lisa Macon Harrison and Prasad V. Rallabhandi and Jane M. Michalski and Xin Zhou and Susan R. Steyert and Stefanie N. Vogel and J. Kaper},
  journal={Infection and immunity},
  year={2008},
  volume={76 12},
  pages={5524-34}
}
Vaccine reactogenicity has complicated the development of safe and effective live, oral cholera vaccines. Delta ctx Vibrio cholerae mutants have been shown to induce inflammatory diarrhea in volunteers and interleukin-8 (IL-8) production in cultured intestinal epithelial cells. Bacterial flagellins are known to induce IL-8 production through Toll-like receptor 5 (TLR5). Since the V. cholerae genome encodes five distinct flagellin proteins, FlaA to FlaE, with homology to conserved TLR5… CONTINUE READING
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Legionella pneumophilainduced NF- B- and MAPK-dependent cytokine release by lung epithelial cells

  • B. Schmeck, P. D. N Guessan, +6 authors S. Hippenstiel
  • Eur. Respir. J. 29:25–33
  • 2007

Toll-like receptor signal transduction

  • J. Krishnan, K. Selvarajo, M. Tsuchiya, G. Lee, S. Choi
  • Exp. Mol. Med
  • 2007

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