Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases.

@article{Suzuki2014VibrioCT,
  title={Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases.},
  author={Masato Fuji Suzuki and Olga Danilchanka and John J Mekalanos},
  journal={Cell host & microbe},
  year={2014},
  volume={16 5},
  pages={
          581-91
        }
}
The cellular surveillance-activated detoxification and defenses (cSADD) theory postulates the presence of host surveillance mechanisms that monitor the integrity of common cellular processes and components targeted by pathogen effectors. Being organelles essential for multiple cellular processes, including innate immune responses, mitochondria represent an attractive target for pathogens. We describe a Vibrio cholerae Type 3 secretion system effector VopE that localizes to mitochondria during… CONTINUE READING
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