Vibrio cholerae: cholera toxin.

  title={Vibrio cholerae: cholera toxin.},
  author={Davy vanden Broeck and Caroline A. J. Horvath and Marc J S De Wolf},
  journal={The international journal of biochemistry & cell biology},
  volume={39 10},
The bacterial protein toxin of Vibrio cholerae, cholera toxin, is a major agent involved in severe diarrhoeal disease. Cholera toxin is a member of the AB toxin family and is composed of a catalytically active heterodimeric A-subunit linked with a homopentameric B-subunit. Upon binding to its receptor, GM0(1), cholera toxin is internalized and transported in a retrograde manner through the Golgi to the ER, where it is retrotranslocated to the cytosol. Here, cholera toxin reaches its… CONTINUE READING