Corpus ID: 237513749

Vibrational density of states capture the role of dynamic allostery in protein evolution

  title={Vibrational density of states capture the role of dynamic allostery in protein evolution},
  author={Tushar Modi and Matthias Heyden and Sefika Banu Ozkan},
Previous studies of the flexibilities of ancestral proteins suggests that proteins evolve their function by altering their native state ensemble. Here we propose a more direct method of visualizing this by measuring the changes in the vibrational density of states (VDOS) of proteins as they evolve. Through analysis of VDOS profiles of ancestral and extant proteins we observe that β-lactamase and thioredoxins evolve by altering their density of states in the terahertz region. Particularly, the… Expand

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