Viable offspring derived from fetal and adult mammalian cells

@article{Wilmut1997ViableOD,
  title={Viable offspring derived from fetal and adult mammalian cells},
  author={Ian Wilmut and Angelika Schnieke and Jim Mcwhir and Alexander J. Kind and Keith Henry Stockman Campbell},
  journal={Nature},
  year={1997},
  volume={385},
  pages={810-813}
}
Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up the adult animal. Transfer of a single nucleus at a specific stage of development, to an enucleated unfertilized egg, provided an opportunity to investigate whether cellular differentiation to that stage involved irreversible genetic modification. The first offspring to develop from a differentiated cell… 
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It is shown that metaphases from ES cells can provide a significantly higher development rate to the morula or blastocyst stage than interphasic nuclei following injection into a recipient oocyte, and the ability of metaphase to be fully reprogrammed was demonstrated.
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The production of cloned animals following nuclear transfer, using somatic cells grown in culture, represents a remarkable feat of developmental biology. It demonstrates the potential of a
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