Viable offspring derived from fetal and adult mammalian cells

@article{Wilmut1997ViableOD,
  title={Viable offspring derived from fetal and adult mammalian cells},
  author={I. Wilmut and A. Schnieke and J. Mcwhir and A. Kind and K. Campbell},
  journal={Nature},
  year={1997},
  volume={385},
  pages={810-813}
}
Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up the adult animal. Transfer of a single nucleus at a specific stage of development, to an enucleated unfertilized egg, provided an opportunity to investigate whether cellular differentiation to that stage involved irreversible genetic modification. The first offspring to develop from a differentiated cell… Expand
Stem Cells and Cloning
Human embryonic stem cells.
Mice cloned from embryonic stem cells.
Nuclear Transfer from Cell Lines
Bovine oocyte cytoplasm supports development of embryos produced by nuclear transfer of somatic cell nuclei from various mammalian species.
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