Vi capsular polysaccharide: Synthesis, virulence, and application

@article{Hu2017ViCP,
  title={Vi capsular polysaccharide: Synthesis, virulence, and application},
  author={Xiaomei Hu and Zhijin Chen and Kun Xiong and Jing Wang and Xiancai Rao and Yanguang Cong},
  journal={Critical Reviews in Microbiology},
  year={2017},
  volume={43},
  pages={440 - 452}
}
Abstract Vi capsular polysaccharide, a linear homopolymer of α-1,4-linked N-acetylgalactosaminuronate, is characteristically produced by Salmonella enterica serovar Typhi. The Vi capsule covers the surface of the producing bacteria and serves as an virulence factor via inhibition of complement-mediated killing and promoting resistance against phagocytosis. Furthermore, Vi also represents a predominant protective antigen and plays a key role in the development of vaccines against typhoid fever… 
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TLDR
The regulatory network of the Vi polysaccharide is reviewed, linking osmolarity and RpoS expression, and how this may impact live attenuated Salmonella vaccine development is discussed.
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TLDR
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TLDR
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