Vgamma9/Vdelta2 T cell activation induced by bacterial low molecular mass compounds depends on the 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid biosynthesis.

@article{Jomaa1999Vgamma9Vdelta2TC,
  title={Vgamma9/Vdelta2 T cell activation induced by bacterial low molecular mass compounds depends on the 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid biosynthesis.},
  author={Hassan Jomaa and Juliane Feurle and K L{\"u}hs and Volker Kunzmann and Hans Peter Tony and Markus Herderich and M. Wilhelm},
  journal={FEMS immunology and medical microbiology},
  year={1999},
  volume={25 4},
  pages={
          371-8
        }
}
Isopentenyl diphosphate (IPP), an important precursor of isoprenoid biosynthesis in prokaryotic and eukaryotic organisms, has been shown to activate Vgamma9/Vdelta2 T cells, the major subset of human gammadelta T cells. The biosynthesis of IPP has been first described as the acetate/mevalonate pathway. Recently, 1-deoxy-D-xylulose 5-phosphate (DOXP) and 2-C-methyl-D-erythritol 4-phosphate have been shown to be key metabolites in the DOXP pathway also leading to the formation of IPP in some… CONTINUE READING
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