Veverimer versus placebo in patients with metabolic acidosis associated with chronic kidney disease: a multicentre, randomised, double-blind, controlled, phase 3 trial

@article{Wesson2019VeverimerVP,
  title={Veverimer versus placebo in patients with metabolic acidosis associated with chronic kidney disease: a multicentre, randomised, double-blind, controlled, phase 3 trial},
  author={Donald Everett Wesson and Vandana S. Mathur and Navdeep Tangri and Yuri Stasiv and Dawn M Parsell and Elizabeth Li and Gerrit San Jose Klaerner and David A. Bushinsky},
  journal={The Lancet},
  year={2019},
  volume={393},
  pages={1417-1427}
}
Effects of veverimer on serum bicarbonate and physical function in women with chronic kidney disease and metabolic acidosis: a subgroup analysis from a randomised, controlled trial
TLDR
Veverimer was effective in treating metabolic acidosis in women with CKD, and significantly improved how they felt and functioned.
Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis (BiCARB): a pragmatic randomised, double-blind, placebo-controlled trial
  • Miles D. Margaret Aimun Michael K. Gowrie Kolitha Deepak Witham Band Ahmed Almond Balasubramaniam Basnayake, M. Witham, A. Avenell
  • Medicine
    BMC Medicine
  • 2020
TLDR
Oral sodium bicarbonate did not improve physical function or renal function, increased adverse events and is unlikely to be cost-effective for use by the UK NHS for this patient group.
Efficacy and Safety of Veverimer in the Treatment of Metabolic Acidosis Caused by Chronic Kidney Disease: A Meta-analysis
TLDR
Current clinical evidence indicates that veverimer is efficacious and safe against metabolic acidosis related to CKD compared with placebo, and further research comparing long-term veVerimer use with traditional alkali therapy is needed.
Effects of Veverimer in Older Adults With CKD and Metabolic Acidosis
Advances in management of chronic metabolic acidosis in chronic kidney disease.
TLDR
Recent studies suggest that sodium bicarbonate therapy may improve vascular endothelial function and muscle mass, and preserve renal function, and could be a potential new therapeutic option for treating chronic metabolic acidosis.
Mechanism of Action of Veverimer: A Novel, Orally Administered, Nonabsorbed, Counterion-Free, Hydrochloric Acid Binder under Development for the Treatment of Metabolic Acidosis in Chronic Kidney Disease
TLDR
Veverimer binds and removes hydrochloric acid from the gastrointestinal tract, resulting in increased serum bicarbonate and the correction of metabolic acidosis, and is appropriate for patients with CKD with and without sodium-sensitive comorbidities.
Hyperkalemia in Chronic Kidney Disease in the New Era of Kidney Protection Therapies
TLDR
K+ pathophysiology and the clinical impact and management of hyperkalemia is reviewed considering these developments and the availability of the novel K+ binders patiromer and sodium zirconium cyclosilicate, recent results from clinical trials targeting metabolic acidosis, and an increasing understanding of the role of the gut microbiota in health and disease.
Effect of Bicarbonate on Net Acid Excretion, Blood Pressure, and Metabolism in Patients With and Without CKD: The Acid Base Compensation in CKD Study.
TLDR
Compared to patients without CKD, those with CKD had lower acid excretion in the form of ammonium but also lower base excretion such as citrate and other organic anions, a potential compensation to preserve acid-base homeostasis.
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