Vestibulotoxicity following aminoglycoside antibiotics and its prevention.


It has been assumed that aminoglycoside-induced damage to the vestibular inner ear ('vestibulotoxicity') is solely due to the inhibition of mitochondrial protein synthesis. There is now substantial evidence, however, to suggest that this form of neurotoxicity is due, at least in part, to the production of free radicals; either in response to excessive… (More)


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