Vestibular morphological analysis of the effects of cisplatin vs. platinum analogs, CBDCA (JM-8) and CHIP (JM-9).

@article{Schweitzer1986VestibularMA,
  title={Vestibular morphological analysis of the effects of cisplatin vs. platinum analogs, CBDCA (JM-8) and CHIP (JM-9).},
  author={Vanessa Gayl Schweitzer and Kyle Eugene Rarey and David F. Dolan and Gary W. Abrams and Carl Sheridan},
  journal={The Laryngoscope},
  year={1986},
  volume={96 9 Pt 1},
  pages={
          959-74
        }
}
Synthetic second generation chemotherapeutic platinum analogs are presently being tested to identify an analog with greater antitumor activity, but less ototoxicity and nephrotoxicity than cisplatin. The objective of this study was to analyze potential vestibular effects of cisplatin and of the two platinum analogs, CBDCA (cis-diammine 1,1-cyclobutane dicarboxylato [2]-0,0(1) platinum or JM-8) and CHIP (cis-dichlorotrans-dihydroxy-bis(isopropylamine) platinum [IV] or JM-9) using scanning and… CONTINUE READING