Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells.

@article{Ingram2005VesselWE,
  title={Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells.},
  author={David A. Ingram and Laura E. Mead and Daniel B. Moore and Wayne Woodard and Amy Fenoglio and Mervin C. Yoder},
  journal={Blood},
  year={2005},
  volume={105 7},
  pages={2783-6}
}
Endothelial progenitor cells (EPCs) can be isolated from adult peripheral and umbilical cord blood and expanded exponentially ex vivo. In contrast, human umbilical vein endothelial cells (HUVECs) or human aortic endothelial cells (HAECs) derived from vessel walls are widely considered to be differentiated, mature endothelial cells (ECs). However, similar to adult- and cord blood-derived EPCs, HUVECs and HAECs derived from vessel walls can be passaged for at least 40 population doublings in… CONTINUE READING
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