Vessel fractions in tumor xenografts depicted by flow- or contrast-sensitive three-dimensional high-frequency Doppler ultrasound respond differently to antiangiogenic treatment.

@article{Palmowski2008VesselFI,
  title={Vessel fractions in tumor xenografts depicted by flow- or contrast-sensitive three-dimensional high-frequency Doppler ultrasound respond differently to antiangiogenic treatment.},
  author={Moritz Palmowski and Jochen Huppert and Peter Hauff and Michael Reinhardt and Karin Schreiner and Michaela A Socher and Peter Hallscheidt and Guenter Werner Kauffmann and Wolfhard Semmler and Fabian Kiessling},
  journal={Cancer research},
  year={2008},
  volume={68 17},
  pages={7042-9}
}
High-frequency volumetric Power Doppler ultrasound (HF-VPDU) captures flow-dependent signals in blood vessels and can be used to assess antiangiogenic therapy effects in rodent tumors. However, the sensitivity is limited to vessels larger than capillaries. Contrast-enhanced HF-VPDU reveals all perfused vessels by assessing stimulated acoustic emissions from disintegrating microbubbles. Thus, we investigated whether flow-sensitive and contrast-enhanced HF-VPDU can depict different vessel… CONTINUE READING