Vessel-Specific Regulation of Angiotensin II Receptor Subtypes During Ovine Development

@article{Cox2005VesselSpecificRO,
  title={Vessel-Specific Regulation of Angiotensin II Receptor Subtypes During Ovine Development},
  author={Blair E. Cox and Xiao-tie Liu and Steven J. Fluharty and Charles R Rosenfeld},
  journal={Pediatric Research},
  year={2005},
  volume={57},
  pages={124-132}
}
Umbilical and systemic responses to angiotensin II differ in term fetal sheep, and peripheral vascular responses are attenuated or absent before and after birth. These observations may reflect developmental differences in angiotensin II receptor (AT) subtypes in vascular smooth muscle (VSM). Studies of AT subtype ontogeny and regulation are generally limited to the aorta, which may not be extrapolated to other arteries, and neither is completely described during ovine development. We therefore… CONTINUE READING