Vesnarinone: a new inotropic agent for treating congestive heart failure.

@article{Cavuolu1995VesnarinoneAN,
  title={Vesnarinone: a new inotropic agent for treating congestive heart failure.},
  author={Erdal Cavuşoğlu and William H. Frishman and Marc Klapholz},
  journal={Journal of cardiac failure},
  year={1995},
  volume={1 3},
  pages={249-57}
}
Vesnarinone is a new and novel inotropic drug that has unique and complex mechanisms of action. It inhibits phosphodiesterase, thereby leading to increased intracellular calcium, and also affects numerous myocardial ion channels, resulting in the prolongation of the opening time of sodium channels and the decrease in the delayed outward and inward rectifying potassium current. In vitro, it has also demonstrated significant effects on cytokine production, which may account for some of its… CONTINUE READING