• Biology, Medicine
• Published in
  Seminars in cell…
  2008
• DOI:10.1016/j.semcdb.2008.08.004

Vesicular trafficking in osteoclasts.

@article{Coxon2008VesicularTI,
  title={Vesicular trafficking in osteoclasts.},
  author={Fraser P. Coxon and Adam Taylor},
  journal={Seminars in cell & developmental biology},
  year={2008},
  volume={19 5},
  pages={
          424-33
        }
}

• Fraser P. Coxon, Adam Taylor

Bone-resorbing osteoclasts are highly dependent on vesicular trafficking pathways that are regulated by Rab GTPases. In particular, polarised transport of acidic vesicles of the endocytic/lysosomal pathway is required for formation of the ruffled border, the resorptive organelle of the osteoclast. The breakdown products of resorption are then transported through the osteoclast by transcytosis, enabling their excretion. In this review, we summarise these trafficking routes, highlight the… CONTINUE READING

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