Vesicular stomatitis virus expressing tumor suppressor p53 is a highly attenuated, potent oncolytic agent.

@article{Heiber2011VesicularSV,
  title={Vesicular stomatitis virus expressing tumor suppressor p53 is a highly attenuated, potent oncolytic agent.},
  author={Joshua F. Heiber and Glen N Barber},
  journal={Journal of virology},
  year={2011},
  volume={85 20},
  pages={10440-50}
}
Vesicular stomatitis virus (VSV), a negative-strand RNA rhabdovirus, preferentially replicates in and eradicates transformed versus nontransformed cells and is thus being considered for use as a potential anticancer treatment. The genetic malleability of VSV also affords an opportunity to develop more potent agents that exhibit increased therapeutic activity. The tumor suppressor p53 has been shown to exert potent antitumor properties, which may in part involve stimulating host innate immune… CONTINUE READING