Vesicular neurotransmitter transporters

@article{Varoqui2007VesicularNT,
  title={Vesicular neurotransmitter transporters},
  author={Hélène Varoqui and Jeffrey D. Erickson},
  journal={Molecular Neurobiology},
  year={2007},
  volume={15},
  pages={165-191}
}
Neurotransmission depends on the regulated release of chemical transmitter molecules. This requires the packaging of these substances into the specialized secretory vesicles of neurons and neuroendocrine cells, a process mediated by specific vesicular transporters. The family of genes encoding the vesicular transporters for biogenic amines and acetylcholine have recently been cloned. Direct comparison of their transport characteristics and pharmacology provides information about vesicular… 
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51 Citations
Highly Influential Citations
5
Background Citations
23
Methods Citations
1
Results Citations
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51 Citations

Molecular, Structural, Functional, and Pharmacological Sites for Vesicular Glutamate Transporter Regulation
TLDR
This review provides an overview of the physiologic sites for VGLUT regulation that could modulate glutamate release in an over-active synapse or in a disease state.
Physiopathological Role of the Vesicular Nucleotide Transporter (VNUT) in the Central Nervous System: Relevance of the Vesicular Nucleotide Release as a Potential Therapeutic Target
TLDR
The physiological relevance of the vesicular nucleotide transport in the central nervous system is analyzed and the possible role of VNUT in the development of some pathological processes, such as chronic neuropathic pain or glaucoma is discussed.
Vesicular neurotransmitter transporter trafficking in vivo: Moving from cells to flies
TLDR
In vivo studies of DVMAT trafficking mutants will allow us to determine how changes in the localization of vesicular transporters affect the nervous system as a whole and complex behaviors mediated by aminergic circuits.
SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine.
Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease
TLDR
The importance of DAT and VMAT2 function in the delicate balance of neuronal dopamine is reviewed, with a new focus on the importance of transporter proteins as both models of human disease and potential drug targets has emerged.
Activity-dependent regulation of vesicular glutamate and GABA transporters: A means to scale quantal size
Sorting of the Vesicular GABA Transporter to Functional Vesicle Pools by an Atypical Dileucine-like Motif
TLDR
Real-time imaging with a VGAT-pHluorin fusion provides a useful approach to explore how unique sorting sequences target individual proteins to synaptic vesicles with distinct functional properties.
Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease
TLDR
This review provides an overview of the current understanding of DAT and VMAT2 neurobiology, including discussion of studies ranging from those conducted in vitro to those involving human subjects and how selected drugs alter the function and expression of these transporters.
Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and Commonalities
TLDR
An overview of glutamate cotransmission in these different classes of neurons is provided, highlighting puzzling differences in the proportion of such neurons expressing a VGLUT in different brain regions and at different stages of development.
From glutamate co-release to vesicular synergy: vesicular glutamate transporters
TLDR
Questions are raised about the morphological and functional organization of neuronal systems endowed with such a dual signalling capacity and the behavioural relevance of this co-phenotype is presently the focus of considerable interest.
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References

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