Vesicular glutamate transporter-dependent glutamate release from astrocytes.

  title={Vesicular glutamate transporter-dependent glutamate release from astrocytes.},
  author={Vedrana Montana and Yingchun Ni and Vice Sunjara and Xue Hua and Vladimir Parpura},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={24 11},
Astrocytes exhibit excitability based on variations of their intracellular Ca2+ concentrations, which leads to glutamate release, that in turn can signal to adjacent neurons. This glutamate-mediated astrocyte-neuron signaling occurs at physiological intracellular Ca2+ levels in astrocytes and includes modulation of synaptic transmission. The mechanism underlying Ca2+-dependent glutamate release from astrocytes is most likely exocytosis, because astrocytes express the protein components of the… CONTINUE READING
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