Vesicular and conductive mechanisms of nucleotide release

@article{Lazarowski2012VesicularAC,
  title={Vesicular and conductive mechanisms of nucleotide release},
  author={Eduardo Rodolfo Lazarowski},
  journal={Purinergic Signalling},
  year={2012},
  volume={8},
  pages={359-373}
}
Extracellular nucleotides and nucleosides promote a vast range of physiological responses, via activation of cell surface purinergic receptors. Virtually all tissues and cell types exhibit regulated release of ATP, which, in many cases, is accompanied by the release of uridine nucleotides. Given the relevance of extracellular nucleotide/nucleoside-evoked responses, understanding how ATP and other nucleotides are released from cells is an important physiological question. By facilitating the… CONTINUE READING
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