Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission

@article{Koo2015VesicularSL,
  title={Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission},
  author={Seong Joo Koo and Gaga Kochlamazashvili and Benjamin R. Rost and Dmytro Puchkov and Niclas Gimber and Martin J. Lehmann and Georgi Tadeus and Jan Schmoranzer and Christian Rosenmund and Volker Haucke and Tanja Maritzen},
  journal={Neuron},
  year={2015},
  volume={88},
  pages={330-344}
}
Neurotransmission depends on synaptic vesicle (SV) exocytosis driven by soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex formation of vesicular synaptobrevin/VAMP2 (Syb2). Exocytic fusion is followed by endocytic SV membrane retrieval and the high-fidelity reformation of SVs. Syb2 is the most abundant SV protein with 70 copies per SV, yet, one to three Syb2 molecules appear to be sufficient for basal exocytosis. Here we demonstrate that loss of the Syb2… CONTINUE READING

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