Vesicular Glutamate Transporter 1 Knockdown in Infralimbic Prefrontal Cortex Augments Neuroendocrine Responses to Chronic Stress in Male Rats.

@article{Myers2017VesicularGT,
  title={Vesicular Glutamate Transporter 1 Knockdown in Infralimbic Prefrontal Cortex Augments Neuroendocrine Responses to Chronic Stress in Male Rats.},
  author={B. A. Myers and Jessica M. McKlveen and Rachel L. Morano and Yvonne M. Ulrich-Lai and Matia B. Solomon and Steven P Wilson and James P Herman},
  journal={Endocrinology},
  year={2017},
  volume={158 10},
  pages={
          3579-3591
        }
}
Chronic stress-associated pathologies frequently associate with alterations in the structure and activity of the medial prefrontal cortex (mPFC). However, the influence of infralimbic cortex (IL) projection neurons on hypothalamic-pituitary-adrenal (HPA) axis activity is unknown, as is the involvement of these cells in chronic stress-induced endocrine alterations. In the current study, a lentiviral-packaged vector coding for a small interfering RNA (siRNA) targeting vesicular glutamate… CONTINUE READING

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