Vesicoureteric reflux in children

@article{Tullus2015VesicouretericRI,
  title={Vesicoureteric reflux in children},
  author={Kjell Tullus},
  journal={The Lancet},
  year={2015},
  volume={385},
  pages={371-379}
}
  • K. Tullus
  • Published 24 January 2015
  • Medicine
  • The Lancet

Figures from this paper

Vesicoureteric Reflux

The retrograde flow of urine predisposes sufferers to acute pyelonephritis by allowing bacteria to travel from the bladder to the usually sterile upper tracts, which can lead to renal scarring and end-stage renal failure.

Vesicoureteral reflux and continuous prophylactic antibiotics

The controversy surrounding VUR management is described, the results of RIVUR trial are highlighted, and how the RIVur findings impact the understanding of CAP in the management of VUR are discussed.

Vesicoureteral reflux and recurrent urinary tract infections

  • Jitendra MeenaP. Hari
  • Medicine
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  • 2019
There is ongoing debate on the aggressiveness of algorithms for diagnosing VUR following UTI, and the risk of end-stage renal failure and hypertension is fairly small with scarring followingUTI.

Vesicoureteral reflux in infants: what do we know about the gender prevalence by age?

The natural history of VUR in infant boys differs from that of infant girls, and therefore requires a gender-specific approach, and available data support the need to redefine the categorization and clinical guidelines for this disease.

Vesicoureteric reflux in children Can intracutaneous sterile water injection be used as a possible treatment for acute renal colic pain in the emergency department?

It is presumed that serum creatinine alone might not be the precise laboratory biochemical parameter to assess renal function and hence, determining the prognosis of primary and secondary VUR as Kari et al.[1] proposed.

Vesicoureteric reflux in children

Children with primary VUR and normal bladder had good-functioning kidneys, while those with secondary VUR associated with abnormal bladder caused by NNB, spina bifida or PUV had abnormal kidney functions.

Intrarenal Reflux

The ability of contrast‐enhanced voiding urosonography to show IRR when it occurs in conjunction with VUR compares favorably to that of fluoroscopic VCUG.

[Clinical features of neurogenic bladder with vesicoureteral reflux in children].

When NB children have the clinical manifestations of non-Escherichia coli urinary tract infection, hydronephrosis, abnormal 99mTc-DMSA renal scanning findings, glomerular proteinuria, increased bladder residual urine volume, and high detrusor leak point pressure, such children may already have VUR, and so diagnosis and intervention should be performed as early as possible.

Children with vesico-ureteric reflux have joint hypermobility and occasional TNXB sequence variants.

An observational study of children with familial and non-familial VUR to determine the prevalence of joint hypermobility, renal scarring, and DNA sequence variants in Tenascin XB found a high prevalence of VUR and jointhypermobility in children followed within a tertiary care pediatric urology clinic.
...

References

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The need for standardized outcome reporting and longer follow-up after endoscopic treatment for long-term outcomes of endoscopic injection in patients with persistent reflux is highlighted.

Endoscopic treatment of primary vesicoureteral reflux.

  • R. Kallen
  • Medicine
    The New England journal of medicine
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It is suggested that every patient with recurrent urinary tract infections, renal damage, and vesicoureteral reflux is a candidate for endoscopic intervention, and the approach suggested by Diamond and Mattoo is destined to overtreat large numbers of children for whom there will not be measurable benefits.

Disappearance of vesicoureteral reflux in children.

This study of an unselected cohort of children with reflux detected after their first known symptomatic urinary tract infection was followed up prospectively for up to 15 years, showing a favorable long-term outcome concerning disappearance of reflux.

Vesicoureteric reflux and renal injury.

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Vesicoureteral reflux in the primate: II Maturation of the ureterovesical junction.

Vesicoureteral reflux in the monkey is frequent, but maturation of the ureterovesical junction occurs by age 3 years and reflux disappears.

Vesicoureteric reflux and timing of micturating cystourethrography after urinary tract infection

The presence and grade of vesicoureteric reflux is not influenced by the timing of the micturating cystourethrogram one week after acute symptomatic UTI, and the MCU need not be deferred for four to six weeks after UTI.

What is the normal prevalence of vesicoureteral reflux

The prevalence of vesicoureteral reflux in normal children is probably significantly higher than the traditional estimates, and this implies that most children with reflux detected by screening do not develop infection.

Vesicoureteral reflux in children with suspected and proven urinary tract infection

The finding supports the claim that VUR is not significantly associated to UTI and that its occurrence among children even without UTI is significantly higher than traditional estimates, and challenges the recommendations of routine VCUG after UTI.

Antimicrobial prophylaxis for children with vesicoureteral reflux.

Among children with vesicoureteral reflux after urinary tract infection, antimicrobial prophylaxis was associated with a substantially reduced risk of recurrence but not of renal scarring.
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