Vesicle size and transmitter release at the frog neuromuscular junction when quantal acetylcholine content is increased or decreased

@article{Kloot2002VesicleSA,
  title={Vesicle size and transmitter release at the frog neuromuscular junction when quantal acetylcholine content is increased or decreased},
  author={W. Kloot and J. Molg{\'o} and R. Cameron and C. Colasante},
  journal={The Journal of Physiology},
  year={2002},
  volume={541}
}
  • W. Kloot, J. Molgó, +1 author C. Colasante
  • Published 2002
  • Chemistry, Medicine
  • The Journal of Physiology
  • We investigated whether the synaptic vesicles at the neuromuscular junction change size when their acetylcholine (ACh) content is altered. The size of the miniature endplate potential (MEPP) increased 3‐ or 4‐fold in preparations pre‐treated in a hypertonic solution in which the anion was gluconate. We measured the dimensions of synaptic vesicles in such preparations and in controls. The size of the vesicles and size distribution were indistinguishable. Quanta contained about half of the usual… CONTINUE READING
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    References

    SHOWING 1-10 OF 41 REFERENCES
    Increasing quantal size at the mouse neuromuscular junction and the role of choline.
    • 22
    Recycling and refilling of transmitter quanta at the frog neuromuscular junction
    • 30
    • Highly Influential
    Nicotinic agonists antagonize quantal size increases and evoked release at frog neuromuscular junction.
    • 5
    Effects of Internal pH on the Acetylcholine Transporter of Synaptic Vesicles
    • 19
    Regulation of Quantal Size by Presynaptic Mechanisms
    • 185
    Pretreatment with hypertonic solutions increases quantal size at the frog neuromuscular junction.
    • 16
    Calcitonin gene‐related peptide acts presynaptically to increase quantal size and output at frog neuromuscular junctions
    • 22
    Effects of activators and inhibitors of protein kinase A on increases in quantal size at the frog neuromuscular junction
    • 17
    • Highly Influential
    Expression of a Putative Vesicular Acetylcholine Transporter Facilitates Quantal Transmitter Packaging
    • 170
    • PDF