Vesicle membrane association of nitric oxide synthase in primary mouse macrophages.

@article{Vodovotz1995VesicleMA,
  title={Vesicle membrane association of nitric oxide synthase in primary mouse macrophages.},
  author={Yoram Vodovotz and David R. Russell and Qiao-wen Xie and Christian Bogdan and Carl Nathan},
  journal={Journal of immunology},
  year={1995},
  volume={154 6},
  pages={2914-25}
}
The isoform of nitric oxide synthase (NOS) whose activity is independent of elevated Ca2+ and exogenous calmodulin (iNOS; NOS type II) is inducible in a wide variety of cells and plays a major role in pathophysiology. The notion that iNOS is predominantly cytosolic is based on studies of a transformed cell line; almost nothing is known about the subcellular localization of iNOS in primary cells. Accordingly, we undertook a combined immunoelectron microscopic and biochemical analysis of iNOS in… CONTINUE READING
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