Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.

@article{Sander2008VesicleAM,
  title={Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.},
  author={Leif E Sander and Simon P C Frank and Seza Bolat and Ulrich Blank and Thierry Galli and Hans Bigalke and Stephan C. Bischoff and Axel Lorentz},
  journal={European journal of immunology},
  year={2008},
  volume={38 3},
  pages={
          855-63
        }
}
Mediator release from mast cells (MC) is a crucial step in allergic and non-allergic inflammatory disorders. However, the final events in response to activation leading to membrane fusion and thereby facilitating degranulation have hitherto not been analyzed in human MC. Soluble N-ethyl-maleimide-sensitive factor attachment protein receptors (SNARE) represent a highly conserved family of proteins that have been shown to mediate intracellular membrane fusion events. Here, we show that mature MC… CONTINUE READING
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