Vesicle Pools: Lessons from Adrenal Chromaffin Cells

@inproceedings{Stevens2011VesiclePL,
  title={Vesicle Pools: Lessons from Adrenal Chromaffin Cells},
  author={David R. Stevens and Claudia Schirra and Ute Becherer and Jens Rettig},
  booktitle={Front. Syn. Neurosci.},
  year={2011}
}
The adrenal chromaffin cell serves as a model system to study fast Ca2+-dependent exocytosis. Membrane capacitance measurements in combination with Ca2+ uncaging offers a temporal resolution in the millisecond range and reveals that catecholamine release occurs in three distinct phases. Release of a readily releasable (RRP) and a slowly releasable (SRP) pool are followed by sustained release, due to maturation, and release of vesicles which were not release-ready at the start of the stimulus… CONTINUE READING
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Synaptobrevin Nterminally bound to syntaxinSNAP25 defines the primed vesicle state in regulated exocytosis

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