Vesicle Fusion Probability Is Determined by the Specific Interactions of Munc18*

@inproceedings{Smyth2010VesicleFP,
  title={Vesicle Fusion Probability Is Determined by the Specific Interactions of Munc18*},
  author={Annya M Smyth and Colin Rickman and Rory R Duncan},
  booktitle={The Journal of biological chemistry},
  year={2010}
}
Mammalian-regulated secretion is absolutely dependent on four evolutionarily conserved proteins: three SNARE proteins and munc18. Dissecting the functional outcomes of the spatially organized protein interactions between these factors has been difficult because of the close interrelationship between different binding modes. Here, we investigated the spatial distribution of single munc18 molecules at the plasma membrane of cells and the underlying interactions between syntaxin and munc18… CONTINUE READING

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