Very mild muscular dystrophy associated with the deletion of 46% of dystrophin

@article{England1990VeryMM,
  title={Very mild muscular dystrophy associated with the deletion of 46% of dystrophin},
  author={S. England and L. Nicholson and M. A. Johnson and S. Forrest and D. Love and E. Zubrzycka-Gaarn and D. Bulman and J. B. Harris and K. Davies},
  journal={Nature},
  year={1990},
  volume={343},
  pages={180-182}
}
  • S. England, L. Nicholson, +6 authors K. Davies
  • Published 1990
  • Biology, Medicine
  • Nature
  • DUCHENNE muscular dystrophy (DMD)1 and Becker muscular dystrophy (BMD), a much milder form of the disease where the age of onset can sometimes be as late as the third or fourth decade of life, are caused by mutations in the same X-linked gene2–7, a 14 kilobase (kb) transcript6,7 which is spread over more than 2 megabases of the human X chromosome8–10. The corresponding protein, dystrophin, has a relative molecular mass of 400,000 (ref. 11). Most mutations causing DMD and BMD are deleá-tions7,12… CONTINUE READING

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