Very low mammographic breast density predicts poorer outcome in patients with invasive breast cancer

@article{Masarwah2015VeryLM,
  title={Very low mammographic breast density predicts poorer outcome in patients with invasive breast cancer},
  author={Amro Masarwah and P{\"a}ivi Auvinen and Mazen Sudah and Suvi Rautiainen and Anna Sutela and Outi Pelkonen and Sanna Oikari and V. M. Kosma and Ritva Vanninen},
  journal={European Radiology},
  year={2015},
  volume={25},
  pages={1875-1882}
}
ObjectivesTo examine the prognostic value of mammographic breast density (MBD) and mammographic features and their relationship with established prognostic factors in patients with invasive breast cancer.MethodsMammographic characteristics of 270 patients were analyzed. MBD was classified according to percentile density (<5 %, 5-10 %, 10-25 %, 25-50 %, 50-75 %, >75 %) and further categorized into very low density (VLD; <10 %), low density (LOD; <25 %) and mixed density (MID; >25… 

Prognostic Influence of Preoperative Mammographic Breast Density in Operable Invasive Female Breast Cancer

Preoperative MBD was a strong independent prognostic factor in operable primary invasive female breast cancer, especially in patients with age >50 years and the HRc(+)/HER2(−) subtype.

The Effect of Breast Parenchymal Density on Breast Cancer Subtypes and Prognostic Factors

Investigation of correlation between breast parenchymal density and prognosis, tumor biology, reoperation rates, and prognostic factors found increased breast density seems to have an effect on indicators of poor prognosis.

Prognostic contribution of mammographic breast density and HER2 overexpression to the Nottingham Prognostic Index in patients with invasive breast cancer

Very low density (VLD) and HER2 positivity were prognostically significant factors independent of the NPI and served to enhance its accuracy, thus offering a readily available and more accurate method for the evaluation of patient prognosis.

The Association Between Mammographic Density and Molecular Subtypes of Breast Cancer

The positive association of high MD with nodal metastasis, advanced stage, multifocality, higher grade, and triple-negative molecular subtype is of great importance for the aggressiveness of the BC.

Correlation of Breast Density Grade on Mammogram With Diagnosed Breast Cancer: A Retrospective Cross-Sectional Study

Most of the breast cancer patients in this population had a mammographic density of B or C, indicating that breast cancer is more common in dense breasts, and future studies need to address and confirm MD and its association with subtypes and aggressiveness of breast cancer.

Mammographic breast density and survival in women with invasive breast cancer.

Higher MBD is one of the strongest independent risk factors for BC, but it seems not to have an unfavorable impact on survival.

Breast Density in a Contemporary Cohort of Women With Ductal Carcinoma In Situ (DCIS)

Women with pure DCIS and higher MBD are more likely to be younger at the time of diagnosis, premenopausal, and Asian, and to present with higher-grade disease.

Exploring the Role of Breast Density on Cancer Prognosis among Women Attending Population-Based Screening Programmes

The findings reinforce the need to improve screening sensitivity among women with dense breasts and to routinely assess breast density, not only for its role as a risk factor for breast cancer but also for its potential influence on cancer prognosis.

The Relationship Between Mammographic Density and Factors Affecting Breast Cancer Risk

Higher MD is related to reproductive risk factors and tumor subtypes, especially Her2 type, in BC patients and further studies are needed to identify the factors related to breast density.

References

SHOWING 1-10 OF 37 REFERENCES

Beyond Breast Cancer: Mammographic Features and Mortality Risk in a Population of Healthy Women

It is indicated that dense area and percent density may relate to survival in healthy women and suggest the potential utility of mammograms beyond prediction of breast cancer risk.

Relationship between mammographic density and breast cancer death in the Breast Cancer Surveillance Consortium.

High mammographic breast density was not associated with risk of death from breast cancer or death from any cause after accounting for other patient and tumor characteristics, and risk factors for the development of breast cancer may not necessarily be the same as factors influencing the risk ofdeath after breast cancer has developed.

Association of Mammographic Density with the Pathology of Subsequent Breast Cancer among Postmenopausal Women

The inverse association between tumor grade and percent density in the symptomatic population could inform the biology of the association between mammographic density and breast cancer risk.

Influence of mammographic parenchymal pattern in screening-detected and interval invasive breast cancers on pathologic features, mammographic features, and patient survival.

The prognosis of screened women presenting with breast cancer is unrelated to dense mammographic parenchymal pattern despite an excess of interval cancers and larger screening-detected tumors in this group.

Breast Density and Parenchymal Patterns as Markers of Breast Cancer Risk: A Meta-analysis

This review explains some of the heterogeneity in associations of breast density with breast cancer risk and shows that, in well-conducted studies, this is one of the strongest risk factors for breast cancer.

Mammographic density and survival in interval breast cancers

In dense breasts, the poorer prognosis of ICs compared to that of screen-detected cancers may be attributable at least partially to later detection, and further studies are warranted to confirm the results.

Size, node status and grade of breast tumours: association with mammographic parenchymal patterns

Women with the P2/DY pattern were twice as likely to have a breast cancer which had already spread to the axillary nodes, compared to women with women with the N1/P1 pattern.

Quantitative classification of mammographic densities and breast cancer risk: results from the Canadian National Breast Screening Study.

Increases in the level of breast tissue density as assessed by mammography are associated with increases in risk for breast cancer, and these results show that increases in theLevel of breast cancer risk associated with increasing mammographic density is shown.

Family History, Mammographic Density, and Risk of Breast Cancer

Examination of family history and percent mammographic density found features of an intermediate marker for breast cancer, and some of the genes that explain variation in percent mammography density might be associated with familial risk of breast cancer.

Relationship between mammographic and histological risk factors for breast cancer.

The results suggest that the radiological patterns referred to as mammographic dysplasia may influence breast cancer risk by virtue of their association with high-risk histological changes in the breast epithelium.