Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistry.

@article{Derijk2003VeryLL,
  title={Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistry.},
  author={Roel H Derijk and Marcel Schaaf and Floor J Stam and Inge E. M. de Jong and Dick F. Swaab and Rivka G. Ravid and E. Vreugdenhil and John Anthony Cidlowski and E. Ron de Kloet and Paul John Lucassen},
  journal={Brain research. Molecular brain research},
  year={2003},
  volume={116 1-2},
  pages={17-26}
}
The hippocampus is an important target for glucocorticoid hormones. Glucocorticoid receptor (GR) mediated feedback in this area is important for control of behavioural adaptation. An alternative splice variant, the GRbeta (GRbeta) isoform, does not bind ligand and has been proposed to inhibit classic GRalpha-mediated transactivation of target genes. Hence, an increased ratio of GRbeta to GRalpha may induce relative corticosteroid-resistance, as e.g. presumed to occur in major depression. To… CONTINUE READING

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