Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.

@article{Boekholdt2014VeryLL,
  title={Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.},
  author={S. Matthijs Boekholdt and G. K. Hovingh and S Jimera Mora and Benoit J. Arsenault and Pierre Amarenco and Terje Rolf Pedersen and John C Larosa and David D Waters and David Demicco and Robert J Simes and Antony C Keech and David M. Colquhoun and Graham A. Hitman and David John Betteridge and Michael B Clearfield and John R. Downs and Helen M. Colhoun and Antonio M. Gotto and Paul M. Ridker and Scott M Grundy and John J. P. Kastelein},
  journal={Journal of the American College of Cardiology},
  year={2014},
  volume={64 5},
  pages={485-94}
}
BACKGROUND Levels of atherogenic lipoproteins achieved with statin therapy are highly variable, but the consequence of this variability for cardiovascular disease risk is not well-documented. OBJECTIVES The aim of this meta-analysis was to evaluate: 1) the interindividual variability of reductions in low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), or apolipoprotein B (apoB) levels achieved with statin therapy; 2) the proportion of patients… CONTINUE READING
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Efficacy and safety of more intensive lowering of LDL cholesterol : a meta - analysis of data from 170 , 000 participants in 26 randomised trials

  • TR Pedersen, AG Olsson, O Faergeman
  • Lancet
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