Very low lead exposures and children's neurodevelopment

@article{Bellinger2008VeryLL,
  title={Very low lead exposures and children's neurodevelopment},
  author={D. Bellinger},
  journal={Current Opinion in Pediatrics},
  year={2008},
  volume={20},
  pages={172–177}
}
  • D. Bellinger
  • Published 2008
  • Medicine
  • Current Opinion in Pediatrics
Purpose of review We remain far from achieving the goal of eliminating lead-associated neurodevelopmental morbidities in children. New evidence regarding the blood lead levels at which morbidities occur have led to calls for the Centers for Disease Control and Prevention to reduce the current screening guideline of 10 μg/dl. The review evaluates the basis for these calls. Recent findings Adverse outcomes, such as reduced intelligence quotient and academic deficits, occur at levels below 10 μg… Expand
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References

SHOWING 1-10 OF 92 REFERENCES
Neurodevelopmental effects of postnatal lead exposure at very low levels.
TLDR
The results consistently show neurobehavioral deficits in relation to low levels of lead in the areas of intelligence, reaction time, visual-motor integration, fine motor skills, attention, including executive function, off-task behaviors, and teacher-reported withdrawn behaviors. Expand
Low-Level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis
TLDR
Environmental lead exposure in children who have maximal blood lead levels < 7.5 μg/dL is associated with intellectual deficits, and an inverse relationship between blood lead concentration and IQ score is found. Expand
Longitudinal Associations Between Blood Lead Concentrations Lower Than 10 μg/dL and Neurobehavioral Development in Environmentally Exposed Children in Mexico City
TLDR
It is indicated that children's neurodevelopment is inversely related to their blood lead levels even in the range of <10 μg/dL, which is consistent with a supralinear relationship betweenBlood lead levels and neurobehavioral outcomes. Expand
Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry.
TLDR
These new follow-up data confirm the previous finding that the TLC regimen of chelation therapy is not associated with neurodevelopmental benefits in children with blood lead levels between 20 and 44 microg/dL (0.96-2.12 micromol/L). Expand
Neuropsychological Function in Children With Blood Lead Levels <10μg/dL
TLDR
The analyses support prior research that children’s blood levels < 10 μg/dL are related to compromised cognition and highlight that these may especially be related to academic achievement. Expand
NEUROPSYCHOLOGICAL FUNCTION IN CHILDREN WITH BLOOD LEAD LEVELS < 10μg/dL
Clear adverse effects of blood lead levels ≥ 10 μg/dL have been documented in children. Given that the majority of US children have levels below 10 μg/dL, clarification of adverse effects below thisExpand
Lead neurotoxicity in children: decomposing the variability in dose-effect relationships.
  • D. Bellinger
  • Medicine
  • American journal of industrial medicine
  • 2007
TLDR
Decomposing the variability in the distribution of observed scores around the best-fit lines that describe the dose-effect relationships for lead neurotoxicity in children is a major research need. Expand
Lead neurotoxicity in children: basic mechanisms and clinical correlates.
TLDR
The present review discusses the current state of knowledge concerning the effects of lead on the cognitive development of children, and suggests that there are toxicological effects with behavioural concomitants at exceedingly low levels of exposure. Expand
Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter.
TLDR
Blood lead concentrations, even those below 10 microg per deciliter, are inversely associated with children's IQ scores at three and five years of age, and associated declines in IQ are greater at these concentrations than at higher concentrations. Expand
A rationale for lowering the blood lead action level from 10 to 2 μg/dL ☆
TLDR
There is now sufficient and compelling scientific evidence for the CDC to lower the blood lead action level in children, and a level of 2 mg/dL is a useful and feasible replacement. Expand
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